Description
What is Cystinuria?
Cystinuria Disease is an inherited autosomal recessive disorder that is characterized by the formation of cystine stones in the kidney, ureter, and bladder. In an affected dog, the kidneys do not adequately reabsorb certain amino acids during the filtering process, thus resulting in excess excretion of these monomers. The amino acids may then precipitate and form crystals or stones in the kidneys, ureters, or bladder, which can be very painful for the dog.
This test is validated for Labrador Retrievers and Newfoundlands only.
Understanding Results
There are 3 possible genotypes reported for Cystinuria Disease:
- CLEAR: those having 2 copies of the normal allele and appear to be normal
- CARRIER: those having 1 copy of the normal allele and 1 copy of the mutation, but appear to be normal
- AFFECTED: those having 2 copies of the mutation and are at risk of developing stones
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