Description
What is Myostatin Deficiency?
Commonly referred to as the “Bully gene” among Whippet breeders, Myostatin Deficiency is inherited as an autosomal recessive trait characterized by a heavy muscling effect among dogs with 2 copies of the mutation.
Understanding Results
Dogs having 1 copy of the mutation (carriers) may appear to be normal phenotypically but on average possess a greater potential for racing. The carrier canines will also likely pass on the Myostatin Deficiency Mutation 50% of the time, therefore a carrier/carrier mating will likely result in producing “Bully”- affected pups in 25% of the offspring.
There are 3 possible genotypes reported for Myostatin Deficiency in Whippets:
- CLEAR: those having 2 copies of the normal allele and appear to be normal
- CARRIER: those having 1 copy of the normal allele and 1 copy of the Myostatin Deficiency mutation and appear to be normal
- AFFECTED: those having 2 copies of the mutation and appear to be more heavily muscled
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